Hepato and Nephro-protective Potentials of Gongronema latifolium in Streptozotocin Induced diabetic Rat Model

Gongronema latifolium (GL) is reported to have hepato-protective and nephron-protective ability. Diabetes associated with liver kidney damage. This work was designed evaluate the effect of ethanolic leaf extract on functions in Streptozotocin-induced diabetic rats. 40 Wistar rats both sexes (150g-200g) were divided into five (n=8). Group 1- normal control (received saline placebo orally). 2 received 200mg/kg GL orally. 3 group administered 65mg/kg streptozotocin (STZ) intraperitoneally for two consecutive days an interval one day between. 4 (diabetic + group) had STZ (65mg/kg i.p.) oral administration GL. 5 treated insulin subcutaneously. Blood samples collected via cardiac puncture assess Liver enzymes activity, Serum electrolytes biomarkers, Urea Creatinine. The Result shows a significant (P<0.05) increase glucose level compared control. Intervention significantly reduced towards normal. activity (p<0.05) increased but (p<0.01) decreased following treatment insulin. Sodium, potassium, chloride, urea creatinine decrease bicarbonate. reversed these changes Results presented that just like possess hypoglycemic, nephro potential. Thus, condition, may exert ameliorative target organs.
 Keywords: Latifolium, Diabetes, insulin, serum electrolytes, enzymes,